There is increase in the number of cases of diabetics day by day. Oxozolone derivatives can desirable to achieve antidiabetic activity. Oxozolone are the compounds reported in many biological activity and we are interested in antidiabetic activity. Hence a series of oxozolone derivatives compounds were taken from Mariappan G for antidiabetic activity. In the present research 10 molecules and 2 standard molecules were studied for the docking study. Orientation pattern, best poses, hydrogen bond interaction were studied for getting the possible significant molecule. The result showed that 2 molecules have shown significant score in docking. Out of that the molecule 3 has shown best score. Docking study was carried out with the software SYBYL X2.0. Computational approach was employed so as to achieve the better chemical entity that can shown the good antidiabetic activity.
Loading....